HIV Mutation Detail Information

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Mutation Information

Mutation Site	K45R
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Relevant Drug	saquinavir (SQV);lopinavir (LPV)

Literature Information

PubMed PMID	16956392
Published Year	2006
Journal	Retrovirology
Title	HIV-2 Protease resistance defined in yeast cells.
Author	M'Barek NB,Audoly G,Raoult D,Gluschankof P
Evidence	When this HIV-2ROD Protease harbours amino acid substitutions known to be involved in HIV-2 PI resistance such as K45R, I54M, or M76V, cell growth, in spite of the presence of the inhibitors, was strongly arrested achieving in some cases only 4% of normal growth (Table 1) demonstrating a tight correlation between resistance, defined in physiological conditions, and loss of susceptibility, defined in our experimental system.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation