Mutation Information
Mutation Site
|
K43E |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
B |
Relevant Drug
|
NRTIs |
Literature Information
PubMed PMID
|
17500586
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2007 |
Journal
|
PLoS computational biology |
Title
|
HIV-1 subtype B protease and reverse transcriptase amino acid covariation. |
Author
|
Rhee SY,Liu TF,Holmes SP,Shafer RW |
Evidence
|
Positively associated mutation pairs consisted primarily of Type I or II thymidine analog mutations (TAMs;as defined in Methods);accessory NRTI mutations that occurred in combination with Type I or II TAMs (K43E, E44D, V118I, H208Y, D218E);and Q151M-associated mutations (V75I, F77L, F116Y).
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