HIV Mutation Detail Information

> K436E Search Result

Mutation Information

Mutation Site	K436E
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag
Combined Mutation	gag.I437T+gag.K436E
Viral Reference	K03455.1
Relevant Drug	PIs

Literature Information

PubMed PMID	17227139
Published Year	2007
Journal	PLoS medicine
Title	A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.
Author	Nijhuis M,van Maarseveen NM,Lastere S,Schipper P,Coakley E,Glass B,Rovenska M,de Jong D,Chappey C,Goedegebuure IW,Heilek-Snyder G,Dulude D,Cammack N,Brakier-Gingras L,Konvalinka J,Parkin N,Kräusslich HG,Brun-Vezinet F,Boucher CA
Evidence	Full genomic sequencing revealed the presence of NC/p1 cleavage site substitutions in the viral Gag polyprotein (K436E and/or I437T/V) in all three resistant viruses.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation