Mutation Information
Mutation Site
|
K42E |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
25383358
|
Published Year
|
2014 |
Journal
|
Molecular therapy. Methods & clinical development |
Title
|
Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. |
Author
|
Wang H,Shun MC,Li X,Di Nunzio F,Hare S,Cherepanov P,Engelman A |
Evidence
|
Here we describe the selection and characterization of the K42E gain-of-function mutation in IN, which greatly improves the efficiency of this system.
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