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Mutation Information
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Mutation Site
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K27M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
|
18039376
|
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Published Year
|
2007 |
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Journal
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Retrovirology |
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Title
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Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages. |
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Author
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Jacquot G,Le Rouzic E,David A,Mazzolini J,Bouchet J,Bouaziz S,Niedergang F,Pancino G,Benichou S |
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Evidence
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In order to define the functional role of Vpr localization at the NE, we have characterized a set of single-point Vpr mutants, and selected two new mutants with substitutions within the first alpha-helix of the protein, Vpr-L23F and Vpr-K27M, that failed to associate with hCG1, but were still able to interact with other known relevant host partners of Vpr.
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HIV Mutation Detail Information