|
Mutation Information
|
Mutation Site
|
K277R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Immune Escape
|
Y |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
30048246
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Extensive host immune adaptation in a concentrated North American HIV epidemic. |
|
Author
|
Brumme ZL,Kinloch NN,Sanche S,Wong A,Martin E,Cobarrubias KD,Sandstrom P,Levett PN,Harrigan PR,Joy JB |
|
Evidence
|
With the exception of the A*03 : 01-associated RT-K277R and A*32 : 01-associated RT-400I mutations whose prevalence declined (albeit not significantly) over the study period, all others increased over time, in seven of 15 cases (46.7%) significantly so.
|
|
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HIV Mutation Detail Information