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Mutation Information
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Mutation Site
|
K25R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
Literature Information
|
PubMed PMID
|
33524070
|
|
Published Year
|
2021 |
|
Journal
|
PLoS pathogens |
|
Title
|
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. |
|
Author
|
Renner N,Mallery DL,Faysal KMR,Peng W,Jacques DA,Böcking T,James LC |
|
Evidence
|
Mutant K25R was substantially more infectious than K25A, with a ~ 1 log reduction in infection, highlighting the importance of maintaining a positive charge at this position.
|
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HIV Mutation Detail Information