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Mutation Information
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Mutation Site
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K22T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
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Viral Reference
|
K03455.1
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Literature Information
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PubMed PMID
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31665623
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Published Year
|
2019 |
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Journal
|
Cell reports |
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Title
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HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. |
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Author
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Salamango DJ,Ikeda T,Moghadasi SA,Wang J,McCann JL,Serebrenik AA,Ebrahimi D,Jarvis MC,Brown WL,Harris RS |
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Evidence
|
For example, R15S, K22T, I31F, R33G, and N48T were predicted to have compromised ability to degrade EGFP-PPP2R5A, and indeed, these substitutions failed to reduce EGFP-PPP2R5A levels compared with wild-type Vif (Figure 1E).
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HIV Mutation Detail Information