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Mutation Information
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Mutation Site
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K22E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
Literature Information
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PubMed PMID
|
16201018
|
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Clinical information
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Yes
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Published Year
|
2005 |
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Journal
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PLoS pathogens |
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Title
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Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. |
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Author
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Simon V,Zennou V,Murray D,Huang Y,Ho DD,Bieniasz PD |
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Evidence
|
However, two Vif variants (V2-5, P3-5) that contained mutations K22E and Y40H, respectively, were unusual in that they did not neutralize APOBEC3G but retained partial activity against APOBEC3F (Figure 3B and 3C).
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HIV Mutation Detail Information