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Mutation Information
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Mutation Site
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K227I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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CA |
Literature Information
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PubMed PMID
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33692109
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Published Year
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2021 |
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Journal
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Science advances |
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Title
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A stable immature lattice packages IP6 for HIV capsid maturation. |
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Author
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Mallery DL,Kleinpeter AB,Renner N,Faysal KMR,Novikova M,Kiss L,Wilson MSC,Ahsan B,Ke Z,Briggs JAG,Saiardi A,Böcking T,Freed EO,James LC |
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Evidence
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We compared the effect of MI treatment on the single-cycle infectivity of HIV-1 mutants K158A/I and K227A/I and found that none of these IP6 binding-deficient mutant viruses were inhibited by any of the MIs tested, in contrast to WT (Fig. 2, A and B).
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HIV Mutation Detail Information