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Mutation Information
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Mutation Site
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K219R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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NRTIs |
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Country
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Zambia |
Literature Information
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PubMed PMID
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32804970
|
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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PloS one |
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Title
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Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia. |
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Author
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Miti S,Handema R,Mulenga L,Mwansa JK,Abrams E,Frimpong C,Burke VM,Zulu M,Siwingwa M,Mwakazanga D,Kalibala S,Denison JA |
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Evidence
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Common TAMs were K70RTQNE (32.8%), K219QE (22.4%), D67N (17.2%) and T215IT (15.5%). The most common NNRTI associated mutation was the K103N (65.5%) which confers resistance to both efavirenz (EFV) and nevirapine (NVP). There was a relatively high occurrence of other NNRTI mutations V106A (36.2%), as well as Y188C (36.2%) and Y181C (36.2%) which confer resistance to etravirine.
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HIV Mutation Detail Information