HIV Mutation Detail Information

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Mutation Information

Mutation Site	K219Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Viral Reference	K03455.1

Literature Information

PubMed PMID	19005273
Disease	HIV infection/AIDS
Published Year	2008
Journal	AIDS (London, England)
Title	Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency.
Author	Harrigan PR,Sheen CW,Gill VS,Wynhoven B,Hudson E,Lima VD,Lecocq P,Aguirre R,Poon AF,Sluis-Cremer N
Evidence	Silent Mutations Compensate for Replication Block of D67N/K70RTo address a possible mechanism by which the silent mutations at codons 65 and 66 in the HIV-1 RT gene might affect virus replication, we assessed the ability of recombinant HIV-1 RT that was WT or contained the TAMs D67N, K70R, T215F and K219Q (TAM67 RT) to copy RNA templates that spanned codons 62 to 77 in RT and included different combinations of mutations at codons 65 (AAA, AGA, AAG), 66 (AAA, AAG), 67 (GAC, AAC) and 70 (AAA, AGA).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation