HIV Mutation Detail Information

> K219Q Search Result


Mutation Information
Mutation Site K219Q
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Viral Reference K03455.1
Literature Information
PubMed PMID 19005273
Disease HIV infection/AIDS
Published Year 2008
Journal AIDS (London, England)
Title Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency.
Author Harrigan PR,Sheen CW,Gill VS,Wynhoven B,Hudson E,Lima VD,Lecocq P,Aguirre R,Poon AF,Sluis-Cremer N
Evidence Silent Mutations Compensate for Replication Block of D67N/K70RTo address a possible mechanism by which the silent mutations at codons 65 and 66 in the HIV-1 RT gene might affect virus replication, we assessed the ability of recombinant HIV-1 RT that was WT or contained the TAMs D67N, K70R, T215F and K219Q (TAM67 RT) to copy RNA templates that spanned codons 62 to 77 in RT and included different combinations of mutations at codons 65 (AAA, AGA, AAG), 66 (AAA, AAG), 67 (GAC, AAC) and 70 (AAA, AGA).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation