HIV Mutation Detail Information

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Mutation Information

Mutation Site	K219E
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	3'-azido-3'-deoxythymidine

Literature Information

PubMed PMID	32747359
Published Year	2020
Journal	Antimicrobial agents and chemotherapy
Title	Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase.
Author	Árquez MA,Martín-Alonso S,Gorelick RJ,Scott WA,Acosta-Hoyos AJ,Menéndez-Arias L
Evidence	In HIV-1, development of resistance to AZT (3'-azido-3'-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e., M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q) in the viral reverse transcriptase (RT).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation