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Mutation Information
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Mutation Site
|
K219E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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zidovudine (AZT) |
Literature Information
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PubMed PMID
|
32129987
|
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Published Year
|
2020 |
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Journal
|
ACS infectious diseases |
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Title
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Defective Strand-Displacement DNA Synthesis Due to Accumulation of Thymidine Analogue Resistance Mutations in HIV-2 Reverse Transcriptase. |
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Author
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Martín-Alonso S,Álvarez M,Nevot M,Martínez MÁ,Menéndez-Arias L |
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Evidence
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In HIV-1, resistance to zidovudine and other thymidine analogues is conferred by different combinations of M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q (designated as thymidine analogue resistance-associated mutations (TAMs)).
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HIV Mutation Detail Information