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Mutation Information
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Mutation Site
|
K219E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
stavudine (D4T);zidovudine (AZT) |
|
Country
|
Cameroon |
Literature Information
|
PubMed PMID
|
30871487
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
BMC infectious diseases |
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Title
|
HIV-1 drug resistance testing is essential for heavily-treated patients switching from first- to second-line regimens in resource-limited settings: evidence from routine clinical practice in Cameroon. |
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Author
|
Takou D,Fokam J,Teto G,Santoro MM,Ceccherini-Silberstein F,Nanfack AJ,Sosso SM,Dambaya B,Salpini R,Billong SC,Gori C,Fokunang CN,Cappelli G,Colizzi V,Perno CF,Ndjolo A |
|
Evidence
|
Of note, TAMs-1 were predominant (T215F/Y: 46.5%;M41 L: 22.8%; L210 W: 8.9%) and associated with higher levels of resistance to both AZT and TDF;as compared to TAMs-2 that had relatively lower prevalence (D67N: 21.8%;K70R: 19.8%; K219Q/E: 18.8%) and were associated preferentially with AZT/D4T-resistance.
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HIV Mutation Detail Information