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Mutation Information
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Mutation Site
|
K219E |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
nevirapine (NPV);efavirenz (EFV) |
|
Country
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Thailand |
Literature Information
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PubMed PMID
|
22132100
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2011 |
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Journal
|
PloS one |
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Title
|
Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis. |
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Author
|
Ngo-Giang-Huong N,Jourdain G,Amzal B,Sang-a-gad P,Lertkoonalak R,Eiamsirikit N,Tansuphasawasdikul S,Buranawanitchakorn Y,Yutthakasemsunt N,Mekviwattanawong S,McIntosh K,Lallemant M,Program for HIV Prevention and Treatment (PHPT) study group. |
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Evidence
|
With NVP, the next two mutations, K219E and T215F, complete the TAM-2 cluster, whereas with EFV, the three TAM-1 mutations (M41L, L210W, and T215Y) appear next, along with the K219E from the TAM-2 pathway.
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HIV Mutation Detail Information