Mutation Information
Mutation Site
|
K211R |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
31120420
|
Published Year
|
2019 |
Journal
|
eLife |
Title
|
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. |
Author
|
Koneru PC,Francis AC,Deng N,Rebensburg SV,Hoyte AC,Lindenberger J,Adu-Ampratwum D,Larue RC,Wempe MF,Engelman AN,Lyumkis D,Fuchs JR,Levy RM,Melikyan GB,Kvaratskhelia M |
Evidence
|
For example, a recent clinical study revealed that failure of DTG treatment in patients was observed with concomitant appearance of IN N155H/K211R/E212T substitutions on the background of the K156N polymorphic mutation .
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