|
Mutation Information
|
Mutation Site
|
K20T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
PIs |
|
Country
|
German |
Literature Information
|
PubMed PMID
|
32556165
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy. |
|
Author
|
Blanch-Lombarte O,Santos JR,Peña R,Jiménez-Moyano E,Clotet B,Paredes R,Prado JG |
|
Evidence
|
Only non-polymorphic and polymorphic PI accessory selected mutations were found in PT1 (K20T), PT4 (A71V) and PT5 (L10V). Genotypes of the Gag region at cleavage site (CS) and non-cleavage site (NCS) mutations are summarized in Table 3.
|
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HIV Mutation Detail Information