|
Mutation Information
|
Mutation Site
|
K20T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
PIs |
|
Country
|
Taiwan(China) |
Literature Information
|
PubMed PMID
|
30122963
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
Infection and drug resistance |
|
Title
|
HIV-1 genotypic drug resistance in patients with virological failure to single-tablet antiretroviral regimens in southern Taiwan. |
|
Author
|
Tsai HC,Chen IT,Lee SS,Chen YS |
|
Evidence
|
For NNRTI, the most common drug resistance-associated mutations were K103N (35.9%), V179D (33.3%), Y181C (12.8%), and L100I (12.8%), while for PI, they were K20T (7.7%) and L90M (5.1%). One of the three patients (33.3%) who failed Triumeq treatment had E138K, G140S, and Q148H INSTI mutations (Figure 4)
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HIV Mutation Detail Information