HIV Mutation Detail Information

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Mutation Information

Mutation Site	K203A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	32960169
Published Year	2020
Journal	eLife
Title	Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author	Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence	Graphed data is the average of two independent experiments and error bars indicate the range. To test these possibilities, we combined the CA destabilizing K203A substitution, which leads to premature disassembly of the CA lattice in vitro, with class II IN substitutions K34A, E87A, and R262A/R263A.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation