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Mutation Information
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Mutation Site
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K19T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Env |
Literature Information
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PubMed PMID
|
31527908
|
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Published Year
|
2019 |
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Journal
|
PLoS pathogens |
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Title
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Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. |
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Author
|
LaBranche CC,Henderson R,Hsu A,Behrens S,Chen X,Zhou T,Wiehe K,Saunders KO,Alam SM,Bonsignori M,Borgnia MJ,Sattentau QJ,Eaton A,Greene K,Gao H,Liao HX,Williams WB,Peacock J,Tang H,Perez LG,Edwards RJ,Kepler TB,Korber BT,Kwong PD,Mascola JR,Acharya P,Haynes BF,Montefiori DC |
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Evidence
|
Overcoming an improbable K19T heavy chain mutation, and induced a neutralization signature consistent with CH235 early precursors in rhesus macaques (Saunders et al.
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HIV Mutation Detail Information