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Mutation Information
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Mutation Site
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K188R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
Literature Information
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PubMed PMID
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18937960
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Published Year
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2008 |
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Journal
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Virology |
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Title
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Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments. |
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Author
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Park R,Heston L,Shedd D,Delecluse HJ,Miller G |
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Evidence
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The most striking observation was that several mutant ZEBRA proteins defective in activating EA-D (R179A, K181A and A185V) and defective in activating lytic viral DNA replication and late genes (Y180E and K188A) were localized to numerous punctate foci. The speckled appearance of R179A and Y180E was more regular and clearly defined in EBV-positive than in EBV-negative 293 cells.
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EBV Mutation Detail Information