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HIV Mutation Detail Information

> K186E Search Result


Mutation Information
Mutation Site K186E
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 32960169
Published Year 2020
Journal eLife
Title Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence Consistent with these observations, a number of substitutions (V165A, K186E, K188E, and K236E) that compromised IN tetramerization also exhibited reduced binding affinity to RNA and failed to bridge between separate RNA oligonucleotides (Figure 5C, Figure 5:figure supplement 1).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation