HIV Mutation Detail Information

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Mutation Information

Mutation Site	K186E
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	31120420
Published Year	2019
Journal	eLife
Title	HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Author	Koneru PC,Francis AC,Deng N,Rebensburg SV,Hoyte AC,Lindenberger J,Adu-Ampratwum D,Larue RC,Wempe MF,Engelman AN,Lyumkis D,Fuchs JR,Levy RM,Melikyan GB,Kvaratskhelia M
Evidence	Individual E11K and K186E IN substitutions fully compromise protein tetramerization (without affecting IN dimerization) due to charge-charge repulsions.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation