Mutation Information
Mutation Site
|
K159P |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
19014595
|
Published Year
|
2008 |
Journal
|
Retrovirology |
Title
|
Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication. |
Author
|
Xu Z,Zheng Y,Ao Z,Clement M,Mouland AJ,Kalpana GV,Belhumeur P,Cohen EA,Yao X |
Evidence
|
In order to further identify the critical amino acid(s) or motif(s) in IN important in the induction of the lethal phenotype, various IN mutants, including F1A, K136A, K159P, V165A, A179P, KR186,7AA, KK215,9AA and RK263,4AA, were introduced into HP16 yeast cells.
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