Mutation Information
Mutation Site
|
K14A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
32960169
|
Published Year
|
2020 |
Journal
|
eLife |
Title
|
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. |
Author
|
Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB |
Evidence
|
Near-complete lack of processing intermediates with the K14A and N18I substitutions, despite the presence of fully processed RT and IN in virions (detected using a separate polyclonal antibody), is likely due to the inaccessibility of epitopes recognized by the monoclonal anti-IN antibody in the processing intermediates.
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