HBV Mutation Detail Information

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Mutation Information

Mutation Site	K141E
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Country	China

Literature Information

PubMed PMID	22634131
Disease	Occult HBV infection
Published Year	2012
Journal	Journal of hepatology
Title	Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors.
Author	Huang CH,Yuan Q,Chen PJ,Zhang YL,Chen CR,Zheng QB,Yeh SH,Yu H,Xue Y,Chen YX,Liu PG,Ge SX,Zhang J,Xia NS
Evidence	Four out of the 13 mutations (C124R, C124Y, K141E, and D144A) strongly decreased the analytical sensitivity of seven commercial HBsAg immunoassays, and 10 (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) significantly impaired virion and/or S protein secretion in both HuH7 cells and mice.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation