|
Mutation Information
|
Mutation Site
|
K136T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Country
|
Cameroon |
Literature Information
|
PubMed PMID
|
32106437
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
International journal of molecular sciences |
|
Title
|
Variability in HIV-1 Integrase Gene and 3'-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy. |
|
Author
|
Acharya A,Tagny CT,Mbanya D,Fonsah JY,Nchindap E,Kenmogne L,Jihyun M,Njamnshi AK,Kanmogne GD |
|
Evidence
|
Integrase polymorphisms in cohort samples: Comparative analyses of cohort subjects infected with CRF02_AG and non-AG subtypes showed that the G134N, I135V, K136T, and T206S polymorphisms were present in a significantly higher proportion of samples with AG subtype (81% to 97%) compared to samples with non-AG subtypes (28-52%) (p < 0.00001, Table 5).
|
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HIV Mutation Detail Information