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HIV Mutation Detail Information

> K136A Search Result


Mutation Information
Mutation Site K136A
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 19014595
Published Year 2008
Journal Retrovirology
Title Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication.
Author Xu Z,Zheng Y,Ao Z,Clement M,Mouland AJ,Kalpana GV,Belhumeur P,Cohen EA,Yao X
Evidence In order to further identify the critical amino acid(s) or motif(s) in IN important in the induction of the lethal phenotype, various IN mutants, including F1A, K136A, K159P, V165A, A179P, KR186,7AA, KK215,9AA and RK263,4AA, were introduced into HP16 yeast cells.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation