|
Mutation Information
|
Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Viral Reference
|
X02763.1;
X65259.1 |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
30472417
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2019 |
|
Journal
|
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |
|
Title
|
The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro. |
|
Author
|
Salpini R,Surdo M,Cortese MF,Palumbo GA,Carioti L,Cappiello G,Spanò A,Trimoulet P,Fleury H,Vecchiet J,Pasquazzi C,Mirabelli C,Scutari R,Sacco A,Alkhatib M,Missale G,Francioso S,Sarmati L,Andreoni M,Angelico M,Ceccherini-Silberstein F,Levrero M,Perno CF,Belloni L,Svicher V |
|
Evidence
|
The presence of K130M/V131I (already known to increase HBV oncogenic potential) was also investigated in HCC and non-HCC groups, as well as their co-occurrence with F30V.
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|
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HBV Mutation Detail Information