|
Mutation Information
|
Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
BCP |
|
Amino acid_Mutation
|
A1762T |
|
Genotype/Subtype
|
B;C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26647737
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2015 |
|
Journal
|
Scientific reports |
|
Title
|
Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients. |
|
Author
|
Yan L,Zhang H,Ma H,Liu D,Li W,Kang Y,Yang R,Wang J,He G,Xie X,Wang H,Wei L,Lu Z,Shao Q,Chen H |
|
Evidence
|
As shown in Fig. 3, besides classical A1762T/G1764A and G1896A mutants affecting codons 130/131 of X gene (K130M/V131I) and codon 28 of PC gene (W28stop), another 12 SNPs (nt.1719, nt.1726, nt.1727, nt.1730, nt.1752, nt.1753, nt.1768, nt.1800, nt.1803, nt.1804, nt.1805 and nt.1825) also caused amino acid changes.
|
|
|
HBV Mutation Detail Information