|
Mutation Information
|
Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
x.V131I+x.K130M |
Literature Information
|
PubMed PMID
|
24346287
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2014 |
|
Journal
|
British journal of cancer |
|
Title
|
HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma. |
|
Author
|
Liu LP,Hu BG,Ye C,Ho RL,Chen GG,Lai PB |
|
Evidence
|
RESULTS: The dual mutations K130M/V131I enhanced the functionality of HBx as they upregulated the expression and transcriptional activity of HIF-1alpha.
|
|
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HBV Mutation Detail Information