Mutation Information
Mutation Site
|
K130M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
X |
Literature Information
PubMed PMID
|
21704589
|
Published Year
|
2011 |
Journal
|
Gastroenterology |
Title
|
Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. |
Author
|
Huang Y,Tong S,Tai AW,Hussain M,Lok AS |
Evidence
|
We also constructed plasmids encoding mutant HBx (K130M, V131I) proteins of all three genotypes, corresponding to the core promoter TA mutation.
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