|
Mutation Information
|
Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Genotype/Subtype
|
C |
Literature Information
|
PubMed PMID
|
21438026
|
|
Published Year
|
2011 |
|
Journal
|
Molecular carcinogenesis |
|
Title
|
Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival. |
|
Author
|
Iyer S,Groopman JD |
|
Evidence
|
This study examines the differential activities between wild-type Hepatitis B virus X protein (WtHBx) and a mutant HBx (MutHBx), which bears a hotspot mutation at nucleotides 1762 and 1764, resulting in a lysine to methionine change at codon 130 and a valine to isoleucine change at codon 131.
|
|
|
HBV Mutation Detail Information