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Mutation Information
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Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
X |
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Combined Mutation
|
x.V131I+x.K130M+x.I127T;x.V131I+x.K130M;x.F132Y+x.V131I+x.K130M |
|
Amino acid_Mutation
|
A1762T |
|
Genotype/Subtype
|
B;C |
Literature Information
|
PubMed PMID
|
16094714
|
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Published Year
|
2005 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated. |
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Author
|
Lin X,Xu X,Huang QL,Liu YQ,Zheng DL,Chen WN,Lin JY |
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Evidence
|
METHODS: Five types of "hot-spot" mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or K130M+V131I+F132Y, respectively, were generated by means of site-directed mutagenesis.
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HBV Mutation Detail Information