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Mutation Information
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Mutation Site
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K12R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
Literature Information
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PubMed PMID
|
20516063
|
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Published Year
|
2010 |
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Journal
|
The Journal of biological chemistry |
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Title
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Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase. |
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Author
|
Murata T,Hotta N,Toyama S,Nakayama S,Chiba S,Isomura H,Ohshima T,Kanda T,Tsurumi T |
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Evidence
|
The K12R mutant of BZLF1, which no longer becomes sumoylated, exhibits stronger transactivation than the wild-type BZLF1 in a reporter assay system as well as in the context of virus genome with nucleosomal structures.
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EBV Mutation Detail Information