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Mutation Information
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Mutation Site
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K122R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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S |
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Combined Mutation
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s.D144E+s.K122R;s.D144E+s.C121R+s.K122R;s.D144E+s.F134L+s.K122R;s.M133I+s.K122R+s.T118K |
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Country
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china |
Literature Information
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PubMed PMID
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32763811
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Disease
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Occult HBV infection
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Published Year
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2020 |
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Journal
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
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Title
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The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients. |
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Author
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Wang J,Liu Y,Liao H,Liu L,Chen R,Si L,Luo D,Huang B,Li L,Jiang J,Xu D |
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Evidence
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The patient was treated with IFN-α+lamivudine, and sK122R-containing mutants persisted during the observation period. Specifically, sK122R, sK122R + D144E, sK122R + C121R + D144E, and sK122R + F134L + D144E mutants respectively comprised 86.4 %, 4.5 %, 4.5 %, and 4.5 % of tested viral clones at the first time-point (sample 1). ;After 4 months of treatment, the sK122R and sK122R + sD144E mutants respectively comprised 95.2 % and 4.8 % of the viral clones in sample 2. ;Testing showed that sT118K + K122R + M133I, sT118K + M133I, and sS143T + A159 G were respectively present in 81.8 %, 9.1 %, and 9.1 % of sample 1 clones and sK122R was predominant in sample 2 (Fig. 2B).;Five viral strains from patient 1, wild-type (WT), sK122R (M1), sK122R + D144E (M2), sK122R + C121R + D144E (M3), and sK122R + F134L + D144E (M4), were transfected into HepG2 cells, and HBV DNA levels were determined in the culture supernatant after 72 h.;Five viral strains from patient 1, wild-type (WT), sK122R (M1), sK122R + D144E (M2), sK122R + C121R + D144E (M3), and sK122R + F134L + D144E (M4), were transfected into HepG2 cells, and HBV DNA levels were determined in the culture supernatant after 72 h.
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HBV Mutation Detail Information