EBV Mutation Detail Information

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Mutation Information

Mutation Site	K122A
Mutation Type	Amino acid level
Gene/Protein/Region Type	BILF1
Viral Reference	NC_007605.1

Literature Information

PubMed PMID	21123379
Published Year	2011
Journal	Journal of virology
Title	The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathways.
Author	Zuo J,Quinn LL,Tamblyn J,Thomas WA,Feederle R,Delecluse HJ,Hislop AD,Rowe M
Evidence	We now demonstrate that disruption of the EKT signaling motif of BILF1 by a K122A mutation impairs the ability of BILF1 to enhance endocytosis of surface MHC-I molecules, while subsequent lysosomal degradation was impaired by deletion of the 21-residue C-terminal tail of BILF1.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation