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Mutation Information
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Mutation Site
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K103S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
AE |
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Relevant Drug
|
NNRTIs;lopinavir (LPV);ritonavir |
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Country
|
China |
Literature Information
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PubMed PMID
|
32183889
|
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Disease
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HIV infection/AIDS
|
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Published Year
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2020 |
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Journal
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Virology journal |
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Title
|
Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China. |
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Author
|
Zou X,He J,Zheng J,Malmgren R,Li W,Wei X,Zhang G,Chen X |
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Evidence
|
K103N/S (41.32%) was the most frequently observed resistance mutation in NNRTIs, followed by Y181C(27.83%) and G190A(26.21%), This is a consequence of the frequent use of NNRTI-based (EFV/NVP) first-line therapy for more than a decade in China, and these results are similar to the data from low- and middle-income countries.
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HIV Mutation Detail Information