HIV Mutation Detail Information

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Mutation Information

Mutation Site	K103N
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	doravirine (DOR)

Literature Information

PubMed PMID	32974670
Published Year	2021
Journal	The Journal of antimicrobial chemotherapy
Title	In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations.
Author	Saladini F,Giammarino F,Hosseini BA,Giannini A,Boccuto A,Dragoni F,Vicenti I,Shafer RW,Zazzi M
Evidence	METHODS: In vitro phenotypic susceptibility to doravirine was assessed in 10 clinically derived infectious clones with intermediate- to high-level resistance to rilpivirine, etravirine, efavirenz and nevirapine, and in NL4-3 site-directed mutants harbouring K103N, Y181C, M230L or K103N/Y181C NNRTI mutations.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation