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Mutation Information
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Mutation Site
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K103N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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NNRTIs;etravirine (ETR);rilpivirine (RPV);doravirine (DOR) |
Literature Information
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PubMed PMID
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32266208
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Published Year
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2020 |
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Journal
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Frontiers in chemistry |
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Title
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In silico Design of Novel HIV-1 NNRTIs Based on Combined Modeling Studies of Dihydrofuro[3,4-d]pyrimidines. |
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Author
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Chen Y,Tian Y,Gao Y,Wu F,Luo X,Ju X,Liu G |
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Evidence
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However, single mutations such as K103N, Y181C, V106A, and L100I in the binding site of the HIV-1 RT might result in decreased inhibitory potencies of NNRTIs, and a double mutation (K103N+Y181C) was more frequently discovered in the process of treating with NNRTIs (Das et al.,).
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HIV Mutation Detail Information