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Mutation Information
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Mutation Site
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K103N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
|
NNRTIs |
Literature Information
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PubMed PMID
|
31767136
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Published Year
|
2020 |
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Journal
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European journal of medicinal chemistry |
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Title
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Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities. |
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Author
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Xiao T,Tang JF,Meng G,Pannecouque C,Zhu YY,Liu GY,Xu ZQ,Wu FS,Gu SX,Chen FE |
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Evidence
|
And also, it displayed potent activities against K103 N (EC50 = 0.077 μM), Y181C (EC50 = 0.11 μM), E138K (EC50 = 0.057 μM), and moderate activity against double mutants RES056 (EC50 = 8.7 μM).
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HIV Mutation Detail Information