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Mutation Information
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Mutation Site
|
K103N |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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nevirapine (NPV);etravirine (ETR);doravirine (DOR) |
Literature Information
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PubMed PMID
|
31370888
|
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Published Year
|
2019 |
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Journal
|
Infectious diseases of poverty |
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Title
|
The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030. |
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Author
|
Ndashimye E,Arts EJ |
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Evidence
|
However, the high HIVDR due to Y181C after NVP exposure necessitates genotypic test before use of ETR as salvage therapy. Doravirine being tested in once daily doravirine/3TC/TDF combination, is more tolerable, has high efficacy, and activity against viruses with resistant mutations K103 N and Y181C.
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HIV Mutation Detail Information