|
Mutation Information
|
Mutation Site
|
K103N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
27267005
|
|
Published Year
|
2016 |
|
Journal
|
European journal of medicinal chemistry |
|
Title
|
Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket. |
|
Author
|
Chen W,Zhan P,Daelemans D,Yang J,Huang B,De Clercq E,Pannecouque C,Liu X |
|
Evidence
|
Additionally, compounds I-8c2 and I-8c3 showed moderate activity against NNRTI resistant strains baring mutations K103N and Y181C with EC50 values of 6.2 μM and 6.8 μM, respectively.
|
|
|
HIV Mutation Detail Information