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Mutation Information
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Mutation Site
|
K101E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
efavirenz (EFV);nevirapine (NVP) |
|
Country
|
Thailand |
Literature Information
|
PubMed PMID
|
22132100
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2011 |
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Journal
|
PloS one |
|
Title
|
Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis. |
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Author
|
Ngo-Giang-Huong N,Jourdain G,Amzal B,Sang-a-gad P,Lertkoonalak R,Eiamsirikit N,Tansuphasawasdikul S,Buranawanitchakorn Y,Yutthakasemsunt N,Mekviwattanawong S,McIntosh K,Lallemant M,Program for HIV Prevention and Treatment (PHPT) study group. |
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Evidence
|
The K103N (P<0.001) and P225H (P<0.001) mutations were each significantly more common and Y181C/I (P = 0.001), G190A (P = 0.002) and K101Q/E (P = 0.003) were each significantly less common among subjects failing efavirenz-based treatment as compared to those failing nevirapine-based treatment.
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HIV Mutation Detail Information