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Mutation Information
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Mutation Site
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I9A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
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Combined Mutation
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vif.V10A+vif.I9A |
Literature Information
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PubMed PMID
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28302150
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Published Year
|
2017 |
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Journal
|
Retrovirology |
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Title
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Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function. |
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Author
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Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK |
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Evidence
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Notably, of the mutants examined, W5A-Q6A, I9A-V10A, H27A-H28A, and D37A-W38A significantly reduced Vif’s ability to bind to CBFβ compared to WT Vif (Fig. 1b; values indicated in green).;Mutants V7A–M8A, I9A–V10A, W11A, and E45A–S46A induced A3G degradation as well as WT Vif.
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HIV Mutation Detail Information