|
Mutation Information
|
Mutation Site
|
I97L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Relevant Drug
|
interferon(IFN) |
Literature Information
|
PubMed PMID
|
20959021
|
|
Published Year
|
2010 |
|
Journal
|
Virology journal |
|
Title
|
Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon α. |
|
Author
|
Zhijian Y,Zhen H,Fan Z,Jin Y,Qiwen D,Zhongming Z |
|
Evidence
|
In this study, we investigated whether HBc protein mutations at hot spots (L60V, S87G and I97L) could still inhibit MxA transcription and the potential significance of this inhibition in virus replication in vitro.
|
|
|
HBV Mutation Detail Information