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HBV Mutation Detail Information

> I97L Search Result


Mutation Information
Mutation Site I97L
Mutation Type Amino acid level
Gene/Protein/Region Type C
Literature Information
PubMed PMID 12050364
Published Year 2002
Journal Journal of virology
Title Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion.
Author Le Pogam S,Shih C
Evidence Here, we further demonstrated that a pre-S1 envelope mutation at position 119, changing an alanine (A) to a phenylalanine (F), can offset the immature secretion phenotype of the mutant I97L (isoleucine to leucine) and successfully restore the wild-type-like selective export of the mature genome of the double mutant pre-S1-A119F/core-I97L.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation