HIV Mutation Detail Information

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Mutation Information
Mutation Site I85V
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug amprenavir (APV)
Literature Information
PubMed PMID 29763303
Published Year 2018
Journal Journal of medicinal chemistry
Title Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
Author Ghosh AK,R Nyalapatla P,Kovela S,Rao KV,Brindisi M,Osswald HL,Amano M,Aoki M,Agniswamy J,Wang YF,Weber IT,Mitsuya H
Evidence The amino acid substitutions identified in the protease-encoding region compared to the wild-type HIV-1NL4-3 were L23I, E34Q, K43I, M46I, I50L, G51A, L63P, A71V, V82A, T91A in HIV-1ATVR5μM; L10F, M46I, I54V, V82A in HIV-1LPVR5μM; or L10F, M46I, I50V, I85V in HIV-1APVR5μM.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation