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Mutation Information
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Mutation Site
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I84V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
|
PIs |
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Country
|
Namibia |
Literature Information
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PubMed PMID
|
30568984
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2018 |
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Journal
|
Open forum infectious diseases |
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Title
|
Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010-2015. |
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Author
|
Sawadogo S,Shiningavamwe A,Roscoe C,Baughman AL,Negussie T,Mutandi G,Yang C,Hamunime N,Agolory S |
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Evidence
|
For protease inhibitors (PIs), the most common mutations observed were as follows: any 37 (10.1%);V82A 25 (6.8%); M46I/L 24 (6.6%); L76V 12 (3.3%); I54V 10 (2.7%); L90M 7 (1.9%);and I84V 6 (1.6%). Of all patients with resistance to PIs (n = 37), 20 (54.1%) also had thymidine analogue mutations (TAMs).
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HIV Mutation Detail Information